Aleksandar Rajkovic, M.D., Ph.D.

  • Professor
  • Department of Obstetrics, Gynecology and Reproductive Science

Education & Training

  • Ph.D. in Molecular Biology from Case Western Reserve University, 1991
  • M.D. from Case Western Reserve University, 1992
  • B.S. in Chemistry from The Johns Hopkins University, 1985

Research Interest Summary

Genomic discoveries and cell based therapeutics

Research Categories

Research Interests

My scientific focus has been on the genetics of reproductive tract development. My laboratory has utilized mouse transgenic models to discover novel transcriptional regulators, which play an important role in male and female gonadal and reproductive tract development. We also conduct genomic studies, utilizing chromosomal microarrays and whole genome sequencing to identify mutations that cause human reproductive pathologies. We use animal models to model mutations and their effect on the gonadal and reproductive tract development. Our studies are currently focused on the ovary, testes and uterine development and genetics of infertility and uterine tumors.

Representative Publications

Pangas S, Choi Y, Ballow D, Zhao Y, Westphal H, Rajkovic A. (2006) Oogenesis requires germ cell- specific transcriptional regulators Sohlh1 and Lhx8. Proc. Natl. Acad. Sci. U.S.A. May 23;103(21):8090-5

Shin Y, Choi Y, Erdin SU, Yatsenko SA, Kloc M, Yang F, Wang PJ, Meistrich ML, Rajkovic, A (2010) Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in Mammalian meiosis. PLoS Genet. 2010 Nov: 6(11):e1001190. PMCID: PMC2973818Choi Y, Qin Y, Berger MF, Ballow DJ, Bulyk ML, Rajkovic A. (2007) Microarray analyses of newborn mouse ovaries lacking Nobox. Biol Reprod. Aug;77(2):312-9.

Choi Y, Ballow DJ, Xin Y, Rajkovic A. (2008) Lim homeobox gene, LHX8, is essential for mouse oocyte differentiation and survival. Biol Reprod. Sep;79(3):442-9. PMCID: PMC2710541.

Zhao H, Chen ZJ, Qin Y, Shi Y, Wang S, Choi Y, Simpson JL, Rajkovic A. (2008) Transcription factor FIGLA is mutated in patients with premature ovarian failure. Am J Hum Genet. Jun;82(6):1342-8. PMCID: PMC2427265

McGuire MM, Yatsenko A, Hoffner L, Jones M, Surti U, Rajkovic A. (2012) Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas. PLoS One. 2012; 7(3):e33251. PMCID: PMC3299761

Suzuki H, Ahn HW, Chu T, Bowden W, Gassei K, Orwig K, Rajkovic A. (2012) SOHLH1 and SOHLH2 coordinate spermatogonial differentiation. Dev Biol. 2012 Jan; 361(2):301-12. PMCID: PMC3249242

Suzuki H, Ahn HW, Chu T, Bowden W, Gassei K, Orwig K, Rajkovic A. (2012) SOHLH1 and SOHLH2 coordinate spermatogonial differentiation. Dev Biol. 2012 Jan; 361(2):301-12. PMCID: PMC3249242

Full List of Publications