Education & Training
- M.D. Freie Universitat Berlin-1999
Research Interest Summary
My research is on the century-old question of whether and to what extent mammalian hearts can regenerate themselves, which is directly related to heart failure, a significant public health problem worldwide. My approach involves basic and translational research and is synergistic with my clinical interest in heart muscle diseases (cardiomyopathy).
My research has three interconnected goals: to understand the mechanisms of cellular growth and proliferation in the heart; to provide mechanistic explanations for the huge variation of regenerative activity seen in biology; and, drawing on the answers to these two fundamental questions, to conduct translational research that implements our basic research results for the diagnosis and treatment of heart failure.
Kühn B, del Monte F, Hajjar RJ, Chang YS, Lebeche D, Arab S, Keating MT. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nat. Med. 2007;13:962-969.
Bersell K, Arab S, Haring B, Kühn B. Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell 2009;138:257-70.
Polizzotti BD, Arab S, Kühn B. Intrapericardial delivery of gelfoam enables the targeted delivery of periostin peptide after myocardial infarction by inducing fibrin clot formation. PLoS One 2012; 7(5): e36788.
Mollova M, Bersell K, Walsh S, Savla J, DasLala T, Park S-Y, Silberstein L, dosRemedios C, Graham D, Colan S, Kühn B. Cardiomyocyte proliferation contributes to post-natal heart growth in humans. Proceedings of the National Academy of Sciences 2013;110(4):1446-1451.
Khaladkar M, Buckley P, Lee MT, Francis C, Eghbal MM, Chuong T, Suresh S, Kühn B, Eberwine J, Kim J. Subcellular RNA sequencing reveals broad presence of cytoplasmic intron-sequence retaining transcripts in mouse and rat neurons. PLoS One 2013;8(10):e76194, PMID: 24098440
Bersell K, Choudhury S, Mollova M, Polizzotti BD, Ganapathy B, Walsh S, Wadugu B, Arab S, Kühn B. Moderate and high amounts of tamoxifen in a-MHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death. Dis. Model. Mech. 2013; 6(6):1459-1469, PMID: 23929941, PMCID: PMC3820268
Polizzotti BD, Ganapathy B, Walsh S, Choudhury S, Ammanamanchi N, Bennet D, dos Remedios C, Haubner BJ, Penninger JM, Kühn B. Stimulation of cardiomyocyte regeneration in neonatal mice and in human myocardium with neuregulin reveals a therapeutic window. Sci. Transl. Med. 2015;7(281):281ra45.
Dueck H, Khaladkar M, Kim TK, Spaethling JM, Francis C, Suresh S, Fisher SA, Seale P, Beck SG, Bartfai T, Kuhn B, Eberwine J, Kim J. Deep sequencing reveals cell-type-specific patterns of single-cell transcriptome variation. Genome Biol. 2015;16:122, PMID: 26056000, PMCID: PMC4480509.
Polizzotti BD, Ganapathy B, Haubner BJ, Penninger JM, Kühn B. A cryoinjury model in neonatal mice for cardiac translational and regeneration research. Nature Protocols 2016; 11: 542–552, PMID: 26890681
Ganapathy B, Polizzotti BD, Bennett D, Nandhagopal N, Kühn B. Neuregulin-1 administration protocols sufficient for stimulating cardiac regeneration in young mice do not induce somatic, organ, or neoplastic growth. PLoS One 2016; 11(5): e0155456, PMID: 27175488.