Jeff Gross, Ph.D.

  • Professor, E. Ronald Salvitti Chair in Ophthalmology Research, Director, Louis J. Fox Center for Vision Restoration
  • Department of Ophthalmology

Education & Training

  • Postdoc 2002-2005 Genetics/Neuroscience Harvard University
  • Ph.D. 2002 Biology Duke University
  • BS. 1996 Biology University of Maryland Baltimore County

Research Interest Summary

Eye Development, Disease and Regeneration

Research Categories

Research Interests

Our research focuses on vertebrate eye development, disease modeling and regeneration utilizing the zebrafish as a model system. Combining forward genetic screens with reverse genetic and embryological manipulations we hope to understand the molecular, cellular and developmental events that regulate eye formation and visual function, ocular diseases and regenerative responses. Current areas of interest in the lab include studies focusing on the development of the retina, lens and retinal pigmented epithelium (RPE), elucidation of the cellular mechanisms that regulate ocular morphogenesis, and the molecular regulation of retina and RPE regeneration. Our research combines molecular, cellular, biochemical, transgenic and in vivo imaging techniques to address these questions. It is our hope that these studies will ultimately lead to a better understanding of visual system disorders such as macular degeneration, cataracts and ocular colobomata that often result in blindness in afflicted patients, and the development of new therapeutic interventions. Finally, we also have an interest in evolution of the eye and have recently initiated studies in squid to address this topic.

Representative Publications

Hanovice N, Daly CMS and JM Gross “N-ethylmaleimide-sensitive factor b (nsfb) is required for normal pigmentation of the zebrafish retinal pigmented epithelium” Investigative Ophthalmology and Visual Science Nov 1;56(12):7535-44 (2015)

Hartsock A, Arnold V, Lee C and JM Gross “In Vivo Analysis of Hyaloid Vasculature Morphogenesis in Zebrafish: A role for the lens in maturation and maintenance of the hyaloid.” Developmental Biology - 394(2):327-39 (2014)

Daly CMS, Willer J, Gregg RG and JM Gross “snow white, a zebrafish model of Hermansky-Pudlak Syndrome Type 5.” Genetics 195(2):481-494. (2013)

Lee J, Lee BK and JM Gross “Bcl6a function is required during optic cup formation to prevent p53-dependent apoptosis and colobomata.” Human Molecular Genetics 22(17):3568-3582 (2013)

Lee J, Cox BD, Daly C, Lee C, Nuckels RJ, Tittle RK, Uribe RA and JM Gross “An ENU mutagenesis screen in zebrafish for visual system mutants identifies a novel splice-acceptor site mutation in patched2 that results in colobomas.” Investigative Ophthalmology and Visual Science 53(13):8214-8221 (2012)

Hayes J, Hartsock A, Napier H, Link BA and JM Gross “Integrin alpha5/Fibronectin and Focal adhesion kinase are required for normal lens development in zebrafish.” Molecular Biology of the Cell 23(24) 4725-4738 (2012)

Uribe RA, Kwon T, Marcotte EM, JM Gross “Id2a functions to limit Notch pathway activity and thereby influence the transition from proliferation to differentiation of retinoblasts during zebrafish retinogenesis.” Developmental Biology 371, 280-292 (2012)

Tittle R, Sze R, Ng A, Nuckels R., Swartz ME, Anderson RM, Bosch J, Stainier DY, Eberhart JK and JM Gross “Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens.” Developmental Biology 350: 50-63 (2011)

Uribe RA and JM Gross “Id2a influences neuron and glia formation in the zebrafish retina by modulating retinoblast cell cycle kinetics.” Development 137: 3763-3774 (2010)

Ng A, Uribe RA, Yieh, L, Nuckels R and JM Gross “Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development.” Development 136:2601-2611. (2009).

 Full List of Publications