Keisuke Ishihara

My group takes a synthetic approach to study how cells form tissues. “Synthetic” embodies the experimental creation of states of physical organization and gene expression that push a multicellular system to all possible extremes. The synthetic approach allows us to discover novel regulatory molecules, dormant genetic programs, and general physical principles, which we will critically evaluate as next generation strategies for organ engineering. My group will quantitatively capture 3D tissue morphogenesis through imaging, computation, and molecular profiling. We will use this knowledge to develop genetic and chemical tools to engineer in vitro tissues such as human brain organoids and cardiac organoids.