Education & Training
- BA, Economics, Cornell University, 2001
- MD, SUNY Stony Brook University School of Medicine, 2010
- Internal Medicine Residency, Columbia-New York Presbyterian Hospital, 2013
- Chief Resident - Internal Medicine, Columbia-New York Presbyterian Hospital, 2014
- Clinical Fellow, Pulmonary, Columbia-New York Presbyterian Hospital, 2017
- Research Fellow, Pulmonary, Columbia-New York Presbyterian Hospital, 2018
Research Interest Summary
Research Categories
Research Interests
My lab’s research focuses on the role of the adaptive immune system in the development of chronic rejection after lung transplantation. Chronic rejection is a progressive airway disease which remains a major limiting factor to long term survival following lung transplantation. Imbalances in the suppression of the adaptive immune system, leading to acute rejection or infection, have been implicated in the pathogenesis of chronic rejection.
Recently, we identified that lung donor memory T cells, the predominant cell in the adaptive immune system, survive following transplantation and persist for weeks to months in the recipient. Furthermore, this survival of donor T cells is associated with improved short-term outcomes. Additionally, we have shown that lung allograft-infiltrating, recipient-derived T cells which migrate to the lungs following transplantation take up residency within the lung. Our lab is focused on determining the function and specificity of these tissue-resident memory T cells and if they are contributing to chronic rejection.
Representative Publications
Snyder ME, Bondonese A, Craig A, Popescu I, Morrell MR, Myerburg MM, Iasella CJ, Lendermon E, Pilweski J, Johnson B, Kilaru S, Zhang Y, Trejo Bittar HE, Wang X, Sanchez PG, Lakkis F, McDyer J. Rate of recipient-derived alveolar macrophage development and major histocompatibility complex cross-decoration after lung transplantation in humans. Am J Transplant. 2021 Aug 24. doi: 10.1111/ajt.16812. Epub ahead of print. PMID: 34431221.
Noda K, Philips BJ, Snyder ME, Phillippi JA, Sullivan M, Stolz DB, Ren X, Luketich JD, Sanchez PG. Heparanase inhibition preserves the endothelial glycocalyx in lung grafts and improves lung preservation and transplant outcomes. Sci Rep. 2021 Jun 10;11(1):12265. doi: 10.1038/s41598-021-91777-0. PMID: 34112915; PMCID: PMC8192744.
Benvenuto L, Snyder ME, Aversa M, Patel S, Costa J, Shah L, Robbins H, D'Ovidio F, Sonett J, Stanifer BP, Lemaitre P, Arcasoy S, Anderson MR. Geographic Differences in Lung Transplant Volume and Donor Availability During the COVID-19 Pandemic. Transplantation. 2021 Apr 1;105(4):861-866. doi: 10.1097/TP.0000000000003600. PMID: 33760792; PMCID: PMC7993650.
Snyder ME, Sembrat J, Noda K, Myerburg MM, Craig A, Mitash N, Harano T, Furukawa M, Pilewski J, McDyer J, Rojas M, Sanchez P. Human Lung-Resident Macrophages Colocalize with and Provide Costimulation to PD1-hi Tissue-Resident Memory T Cells. Am J Respir Crit Care Med. 2021 May 15;203(10):1230-1244. doi: 10.1164/rccm.202006-2403OC. PMID: 33306940.
Snyder ME, Farber DL. Human lung tissue resident memory T cells in health and disease. Curr Opin Immunol. 2019 Aug; 59:101-108. doi: 10.1016/j.coi.2019.05.011. Epub 2019 Jun 29. PMID: 31265968; PMCID: PMC6774897.
Szabdo PA, Levitin HM, Miron M, Snyder ME, Senda T, Yuan J, Cheng YL, Bush EC, Dogra P, Thapa P, Farber DL, Sims PA. Single cell transcriptome profiling defines activation states and interrelatedness between human blood and tissue T cells. Nature Communications. 2019; 10:4076.
Weisberg SP, Carpenter DJ, Chait M, Dogra P, Gartrell-Corrado RD, Chen AX, Campbell S, Liu W, Saraf P, Snyder ME, Kubota M, Danzi NM, Schrope BA, Rabadan R, Saenger Y, Chen X, Farber DL. Tissue-Resident Memory T Cells Mediate Immune Homeostasis in the Human Pancreas through the PD-1/PD-L1 Pathway. Cell Rep. 2019; Dec 17;29(12): 3916-3932.e5.
Snyder ME, Finlayson MO, Connors TJ, Senda T, Bush E, Carpenter D, Marboe C, Benvenuto L, Shah L, Robbins H, Hook JL, Sykes M, D'Ovidio F, Bacchaetta M, Sonett JR, Lederer DJ, Arcasoy S, Sims PA, Farber DL. Generation and persistence of human tissue-resident memory T cells in lung transplantation. Science Immunology. 2019; Mar 8; 4(33): eaav5581.
Senda T, Dogra P, Granot T, Furuhaushi K, Snyder ME, Carpenter DJ, Szabo PA, Thapa P, Miron M, Farber DL. Macroanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life. Mucosal Immunology. 2018; In Press.
Singer JP, Peterson ER, Snyder ME, Katz PP, Golden JA, D'Ovidio F, Bacchetta M, Sonett JR, Kukreja J, Shah L, Robbins H, Van Horn K, Shah RJ, Diamond JM, Wickersham N, Sun L, Hays S, Arcasoy SM, Palmer SM, Lederer DJ. Body Composition and Mortality after Adult Lung Transplantation in the United States. Am J Respir Crit Care Med. 2014; 190(9): 1012-1021.