Xiangyun Wei, Ph.D.

  • Associate Professor
  • Department of Opthalmology

Education & Training

  • Ph.D. in Cell Biology from State University of New York at Buffalo, 1998
  • M.S. in Cell Biology from Institute of Botany, Chinese Academy of Sciences, China, 1992
  • B.S. in Biological Sciences from Northeast Normal University, China, 1989

Research Interest Summary

Our lab studies retinal development, degeneration, and regeneration in zebrafish

Research Categories

Research Interests

Polarity proteins

The zebrafish retina develops from a polarized undifferentiated neuroepithelium into a functional tissue of complex cytoarchitecture. We are interested in understanding how the polarity proteins regulate this remarkable morphogenetic process during development as well as in how polarity proteins maintain photoreceptor survival in developed mature retina. 

Chromatin organization

Growing evidence demonstrates that dynamic chromatin organization play essential roles in genomic functions. However, the mechanisms of chromatin organization remain poorly understood. We are interested in the chromatin biology and epigenetic regulations of retinal development and aging. Our current focus is to understand how cell-type-specific chromatin organizations underlie gene expression regulations and how such chromatin organizations play critical roles in maintaining photoreceptor health.

Representative Publications

J. Zou, X. Wang, and X. Wei (2012) Crb apical polarity proteins maintain zebrafish retinal cone mosaics via intercellular binding of their extracellular domains. Developmental Cell. 22, 1261–1274.

X. Yang, J. Zou, D. Hyde, L. Davidson, and X. Wei (2009) Stepwise maturation of apicobasal polarity of the neuroepithelium is essential for vertebrate neurulation. Journal of Neuroscience. 29:11426-11440.

J. Zou, K. Lathrop, M. Sun, X. Wei (2008) Intact RPE maintained by Nok is essential for retinal epithelial polarity and cellular patterning in zebrafish. Journal of Neuroscience. 28(50):13684 –13695.

X. Wei, S. Somanathan, J. Samarabandu and R. Berezney. (1999). Three-dimensional visualization of transcription sites and their association with splicing factor-rich nuclear speckles. Journal of Cell Biology 146:543-558.

X. Wei, J. Samarabandu, R.S. Devdhar, A. Siegel. R. Acharya, R. Berezney. (1998) Segregation of transcription and replication sites into higher order domains. Science. 281:1502-1505.