Education & Training
- Ph.D., Carnegie Mellon University
Research Interest Summary
Research Categories
Research Interests
The overarching goal for the “MuSIC 4 MIND” lab is to understand how brain functions, the placenta-brain axis, and the heart-brain connection by launching novel sensitive imaging methodology: (A) to understand etiology and reveal what cannot be seen, understood, or appreciated with the current clinical practice by developing more sensitive advance imaging methods; (B) to facilitate early detection and diagnosis before irreversible tissue damage occurs to allow timely intervention; and (C) to establish non-invasive imaging-based surrogate biomarkers for guiding therapeutic development and efficacy. The current research programs entail leveraging the novel imaging methods to guide molecular investigation of mitochondrial involvement in epilepsy, traumatic brain injury, post-traumatic epileptogenesis, fetal alcohol syndrome, in utero exposure on neurodevelopment, placenta-brain axis in fetal neurodevelopment in congenital heart disease, childhood-onset epileptic encephalopathy, mitochondrial disorders, and developmental origin of late-onset neurodegenerative diseases in rodent models.
Representative Publications
Stapleton MC, Koch SP, Cortes DRE, Wyman S, Schwab KE, Mueller C, McKennan CG, Boehm-Sturm P, Wu YL (2023) Apolipoprotein-E (ApoE) Deficiency Leads to Brain Network Alteration Characterized by Diffusion MRI and Graph Theory. Frontiers in neuroscience. 2023, doi:10.3389/fnins.2023.1183312. PMID: 38075287; PMCID: PMC10702609.
Turan S, Chaillet JR, Stapleton MC, Wu YL. Genome Editing and Myocardial Development. Advances in experimental medicine and biology. 2023;1396:53-73. Epub 2022/12/02. doi: 10.1007/978-981-19-5642-3_4. PubMed PMID: 36454459.
Wu YL. Cardiac MRI Assessment of Mouse Myocardial Infarction and Regeneration. Methods Mol Biol. 2021;2158:81-106. doi: 10.1007/978-1-0716-0668-1_8. PubMed PMID: 32857368.
Wu Y, Pearce PS, Rapuano A, Hitchens TK, de Lanerolle NC, Pan JW. Metabolic changes in early poststatus epilepticus measured by MR spectroscopy in rats. J Cereb Blood Flow Metab. 2015 Nov;35(11):1862-70. PubMed PMID: 26104287; PubMed Central PMCID: PMC4635243.
Chen Z, Stapleton MC, Xie Y, Li D, Wu YL, Christodoulou AG. Physics-informed deep learning for T2-deblurred superresolution turbo spin echo MRI. Magnetic resonance in medicine. 2023. Epub 2023/08/14. doi: 10.1002/mrm.29814. PubMed PMID: 37578085.
Shang P, Simpson JD, Taylor GM, Sutherland DM, Welsh OL, Aravamudhan P, Natividade RDS, Schwab K, Michel JJ, Poholek AC, Wu Y, Rajasundaram D, Koehler M, Alsteens D, Dermody TS. Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus. Nature Commun. 2023;14(1):2615. Epub 2023/05/06. doi: 10.1038/s41467-023-38327-6. PubMed PMID: 37147336; PMCID: PMC10163058.
Golbourn BJ, Halbert ME, Halligan KE, Varadharajan S, Krug B, Mbah N, Kabir N, Stanton AJ, Locke A, Casillo S, Zhao Y, Sanders L, Cheney A, Mullett SJ, Mirhadi S, McCarl L, Chang Y-F, Wu YL, Gatesman TA, Cruz AF, Zapotocky M, Hu B, Kohanbash G, Wang X, Vartanian A, Moran M, Lieberman F, Amankulor NM, Wendell SG, Morozova O, Panigrahy A, Felker J, Bertrand KC, Kleinman C, Rich JN, Broniscer A, Lyssiotis C, Jabado N, Pollack IF, Mack SC and Agnihotri S. Loss of MAT2A and methionine dependency are indispensable for H3K27M mutant gliomas. Nature Cancer. 2022, May;3(5):629-648, PMID: 35422502, DOI: 10.1038/s43018-022-00348-3
Kapralov AA, Yang Q, Dar HH, Tyurina YY, Anthonymuthu TS, Kim R, St Croix CM, Mikulska-Ruminska K, Liu B, Shrivastava IH, Tyurin VA, Ting HC, Wu YL, Gao Y, Shurin GV, Artyukhova MA, Ponomareva LA, Timashev PS, Domingues RM, Stoyanovsky DA, Greenberger JS, Mallampalli RK, Bahar I, Gabrilovich DI, Bayir H, Kagan VE. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Nature Chem Biol. 2020;16(3):278-90. Epub 2020/02/23. doi: 10.1038/s41589-019-0462-8. PMID: 32080625. PMCID: PMC7233108.
Liu X, Yagi H, Saeed S, Bais AS, Gabriel GC, Chen Z, Peterson KA, Li Y, Schwartz MC, Reynolds WT, Saydmohammed M, Gibbs B, Wu Y, Devine W, Chatterjee B, Klena NT, Kostka D, de Mesy Bentley KL, Ganapathiraju MK, Dexheimer P, Leatherbury L, Khalifa O, Bhagat A, Zahid M, Pu W, Watkins S, Grossfeld P, Murray SA, Porter GA Jr, Tsang M, Martin LJ, Benson DW, Aronow BJ, Lo CW. The complex genetics of hypoplastic left heart syndrome. Nature Genetics. 2017 Jul;49(7):1152- 1159. PubMed PMID: 28530678
Wu YL, Ye Q, Foley LM, Hitchens TK, Sato K, Williams JB, Ho C. In situ labeling of immune cells with iron oxide particles: an approach to detect organ rejection by cellular MRI. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1852-7. PubMed PMID: 16443687; PubMed Central PMCID: PMC1413627.